The Relationship between Vitamin D Status and the Menstrual Cycle in Young Women: A Preliminary Study

Nutrients. 2018 Nov 11;10(11):1729. doi: 10.3390/nu10111729.

Abstract

Background: The aim of this study was to evaluate serum vitamin D levels and to compare these with the menstrual cycle in young women with different body weights.

Methods: Eighty-four students were recruited into the study of which 77 remained at the study's completion. Women were assigned to one of two subgroups, according to their 25-hydroxy vitamin D test level [25(OH)D] in which 60 women had low 25(OH)D levels (LD < 30 ng/mL) and 17 had normal levels (ND > 30 ng/mL ≤ 80 ng/mL).

Results: In the LD group, 40% of participants reported having long cycles, 27% were classified as having oligomenorrhoea, and 13% as having amenorrhoea. In the ND group, only 12% reported menstrual cycle disorders, 6% had oligomenorrhoea, and 6% had amenorrhoea. Women who did not meet the recommended level of 30 ng/mL of 25(OH)D had almost five times the odds of having menstrual cycle disorders as women who were above the recommended vitamin D level.

Conclusion: A relationship was demonstrated between the frequency of menstrual disorders and low levels of vitamin D. Supplementation is necessary in women with low levels of vitamin D in order to compensate for this deficiency and to assess its effect in regulating menstrual disorders.

Keywords: 25(OH)D; menstrual cycle; nutritional status; vitamin D.

MeSH terms

  • Adult
  • Amenorrhea / blood
  • Amenorrhea / etiology
  • Body Mass Index
  • Body Weight
  • Female
  • Humans
  • Menstrual Cycle*
  • Menstruation Disturbances / blood
  • Menstruation Disturbances / etiology*
  • Prevalence
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood
  • Vitamin D Deficiency / blood
  • Vitamin D Deficiency / complications*
  • Vitamin D Deficiency / epidemiology
  • Young Adult

Substances

  • Vitamin D
  • 25-hydroxyvitamin D